Clinical Research Directory

Inclusion Criteria: 1. Adults (18-65 years) 2. ≥ 1-year history of migraine with or without aura according to the International Classification of Headache Disorders (ICHD-3) diagnostic criteria 3. Known chronic migraine (headache occurring ≥ 15 days per month for \> 3 months, which on at least 8 days per month has the features of migraine headache) diagnosed before age 50 4. Qualifying for preventive migraine treatment (screened by neurologist) 5. Ability to speak and read Danish Exclusion Criteria: 1. Use of onabotulinumtoxinA as preventive migraine treatment during the 4 months before screening 2. Use of other preventive migraine treatment other than CGRP antagonists (However, participants are allowed to be on one stable preventive medication (antidepressant, calcium channel blockers, beta blockers or antiepileptic)- 2 months prior to screening until end of study , if necessary), devices for migraine prevention such as transcranial magnetic stimulation and use of nerve blocks 3 months prior to screening 3. Use of opioid or barbiturate medications in the last four weeks before participation in the study 4. Secondary headache disorders including medication overuse headache 5. Severe psychiatric, vascular disease, or known liver disease 6. Alcohol abuse, drug abuse, or substance abuse 7. Current or planned pregnancy and lactation