Clinical Research Directory

Inclusion Criteria: * Voluntary participation with written informed consent * Male ≥ 65 years or postmenopausal female * Diagnosed with sarcopenia: * ASM \< 7.0 kg/m² (men) or \< 5.4 kg/m² (women) * Plus low handgrip strength or SPPB ≤ 9 * MNA screening score ≥ 8 * Body weight ≥ 35 kg, BMI between 15-30 kg/m² * Willing and able to follow exercise and nutrition guidance Exclusion Criteria: * Allergy to investigational drug * History of GI bleeding, ulcers, or severe liver/kidney/heart disease * QTc ≥ 450 ms with symptoms * Severe COPD, uncontrolled diabetes or thyroid disease * Diseases causing cachexia or muscle wasting (e.g., ALS, Parkinson's) * Vitamin D deficiency (\<10 ng/mL), hemoglobin \<10 g/dL * Severe psychiatric disorders or MMSE \< 21 * Inability to walk or recent fracture/surgery affecting mobility * Use of prohibited medications or recent participation in other clinical trials * Investigator deems the subject unsuitable for the study