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Corneal Neurotization vs. Cenergermin for Neurotrophic Keratitis: A Pilot Study
Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Summary
This pilot study evaluates the feasibility and outcomes of two treatment approaches for corneal sensory dysfunction due to neurotrophic keratitis (NK): corneal neurotization surgery and topical Cenergermin (Oxervate). Participants will receive treatment based on clinical decision-making, not randomization, and will be followed for 12 months through eight visits at the Ivey Eye Institute, St. Joseph's Health Care London. Data collected during routine eye examinations and validated quality-of-life questionnaires will be used to assess visual outcomes, corneal structure and function, and patient-reported well-being. This feasibility study is funded by the Lawson Research Institute Internal Research Fund and is intended to generate preliminary evidence for a future randomized trial.
Official title: Corneal Neurotization: A Study on the Outcomes of Nerve Repair for Corneal Sensory Dysfunction
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-08-01
Completion Date
2027-08-01
Last Updated
2025-07-18
Healthy Volunteers
No
Conditions
Interventions
Corneal Neurotization
Surgical technique involving the transfer of healthy donor sensory nerves to the anesthetic cornea to restore corneal innervation and sensation in patients with neurotrophic keratitis.
Cenergermin
Topical recombinant human nerve growth factor (rhNGF) approved for the treatment of neurotrophic keratitis. Administered as eye drops, it promotes epithelial healing and nerve regeneration.
Locations (1)
Ivey Eye Institute, St. Joseph's Health Care London
London, Ontario, Canada