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NOT YET RECRUITING
NCT07073924
NA

Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support

Sponsor: University of Pittsburgh

View on ClinicalTrials.gov

Summary

In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two high-priority interventions: sterile injection equipment and daily oral HIV pre-exposure prophylaxis (PrEP). Outpatient clinics represent an opportune venue to implement these interventions. Yet most clinical providers in these settings do not currently provide them, contributing to a wide gap between evidence and routine practice. The Prescribe to Prevent HIV (P2PH) trial is a participatory study designed to co-develop and pilot test a set of implementation strategies to support outpatients clinics in offering sterile injection equipment and PrEP with the goal of reducing the risk of HIV and SIRI among PWID.

Official title: Prescribe to Prevent HIV (P2PH): Enhancing Clinic-based Prescribing of Harm Reduction: A Clinical Trial to Prevent HIV and Severe Injection-related Infections Among PWID

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

536

Start Date

2026-08-01

Completion Date

2028-06

Last Updated

2026-03-04

Healthy Volunteers

No

Interventions

BEHAVIORAL

Implementation strategy bundle

The anticipated strategy bundle will include integrated patient-, provider-, and system-level interventions to support sustainable implementation. At the patient level, this may involve education, peer support, and navigation services; at the provider level, training, decision-support tools, and workflow enhancements; and at the system level, policy changes, electronic health record integration, and organizational alignment to promote and maintain prescribing of PrEP and injection equipment.

Locations (4)

Latterman Family Health Center

Pittsburgh, Pennsylvania, United States

Center for Psychiatric And Chemical Dependency Services

Pittsburgh, Pennsylvania, United States

Internal Medicine Recovery Engagement Program

Pittsburgh, Pennsylvania, United States

UPMC Magee-Womens Hospital

Pittsburgh, Pennsylvania, United States