Clinical Research Directory

Inclusion Criteria: 1. Outpatients or inpatients meeting DSM-5 diagnostic criteria forschizophrenia; 2. Aged 18-65 years (inclusive), regardless of gender; 3. Currently receiving first- or second-generation oral antipsychotics (excluding clozapine) with stable condition as assessed by the investigator, and PANSS total score ≤80 at screening and baseline; 4. Signed informed consent by the patient and/or guardian; Exclusion Criteria: 1. Comorbid psychiatric diagnoses other than schizophrenia; 2. Severe physical diseases, intellectual disability, organic brain disorders, or mental disorders due to physical illnesses; 3. QTc interval \>450 ms (male) or \>460 ms (female); 4. History of psychoactive substance abuse (excluding tobacco) within the past 12 months, or significant suicidal/violent tendencies; 5. Current or history of tardive dyskinesia (TD), neuroleptic malignant syndrome (NMS), or severe extrapyramidal symptoms (EPS); 6. Treatment-resistant schizophrenia (failure of ≥2 adequate antipsychotic regimens of different compounds); 7. Hypersensitivity or inefficacy to risperidone or paliperidone; 8. Pregnancy, lactation, planned pregnancy, or failure to use effective contraception during the study; 9\. Other conditions deemed unsuitable by the investigator. \|