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The Effect of Dapagliflozin on Patients With Cardiomyopathy
Sponsor: May Mohamed Abdalla
Summary
This randomized controlled trial evaluates the efficacy and tolerability of early initiation of dapagliflozin in adult patients hospitalized with acute heart failure (AHF). The study aims to assess the effect of dapagliflozin on pulmonary congestion as measured by lung ultrasound (LUS), length of hospital stay, and cardiac and renal biomarkers. A total of 100 patients will be randomized into two groups: one receiving dapagliflozin plus diuretics and the other receiving diuretics alone. Key outcomes include the reduction of extravascular lung water (assessed by B-lines in LUS), improved diuretic response, changes in NT-proBNP, sST2, CA-125, and NGAL levels, and incidence of acute kidney injury. The study will be conducted at the Cardiology and ICU departments at Kasr Al Ainy Hospital, Cairo University
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-08
Completion Date
2026-05
Last Updated
2025-08-22
Healthy Volunteers
No
Conditions
Interventions
Dapagliflozin (DAPA)
Receives dapagliflozin 10 mg once daily + standard intravenous diuretic therapy
Diuretic
Arm B (Control Group): Receives standard intravenous diuretic therapy alone
Locations (1)
Cairo University
Cairo, Egypt