Clinical Research Directory

Inclusion Criteria: * 18 ≤ Age ≤ 75 years old, regardless of gender. * ALS patients with confirmed SOD1 gene mutations (known SOD1 mutation sites with reported relevant disease progression). * The diagnosis meets the criteria for definite or probable familial or sporadic ALS in the El Escorial diagnostic criteria for amyotrophic lateral sclerosis revised by the World Federation of Neurology. * The patient himself/herself or their legal representative clearly understands, voluntarily participates in this study, and signs the informed consent form. Exclusion Criteria: * Patients with SOD1 mutation sites occurring at nucleotides 44 - 66 (counting from the start of SOD1 protein translation) and patients with P.F21C mutation. * Patients diagnosed with other mental illnesses according to the DSM - V diagnostic criteria, or those with obvious suicidal intent. * Patients with severe hepatic insufficiency, severe renal insufficiency, or severe cardiac insufficiency. (Severe hepatic insufficiency refers to an ALT value ≥ 2.0 times the upper limit of normal or an AST value ≥ 2.0 times the upper limit of normal; severe renal insufficiency refers to a CRE ≥ 1.5 times the upper limit of normal or an eGFR \< 40 mL/min/1.73m²; severe cardiac insufficiency refers to a NYHA score of 3 - 4.) * Patients with a history of alcohol or drug abuse. * Pregnant, lactating patients, those with a possibility of pregnancy, or patients planning to become pregnant. * Patients who have received any vaccination within 28 days. * Patients who are unable to cooperate with the follow - up for other reasons.