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Discovery of HPV T Cell Epitopes and Development of Multi-epitope Vaccines
Sponsor: Anhui Provincial Hospital
Summary
Based on the trend that the incidence and mortality of cervical carcinoma among female cancers worldwide are increasing year by year, the investigators aim to develop a multi-epitope therapeutic vaccine capable of simultaneously activating humoral and cellular immune responses, which is achieved by fusing multiple T-cell epitope immunostimulatory proteins. To obtain information on functional T-cell epitopes to be included in the vaccine, the investigators conducted research starting from clinical cases. By collecting peripheral blood and cancerous tissues from clinical patients, the investigators isolated reactive T-cells and screened for information on T-cell epitopes of HPV antigens.
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2025-09-01
Completion Date
2033-09-01
Last Updated
2025-07-22
Healthy Volunteers
No
Conditions
Locations (1)
Anhui Provincal Hospital
Hefei, Anhui, China