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A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Risk-Stratified Screening Strategy for Lung Cancer
Sponsor: The First Affiliated Hospital of Guangzhou Medical University
Summary
A nationwide population-based multi-center RCT enrolling ≥60,000 eligible residents to compare screening effectiveness between risk-prediction-model-driven and traditional guideline-based high-risk lung cancer screening strategies.
Key Details
Gender
All
Age Range
40 Years - 74 Years
Study Type
INTERVENTIONAL
Enrollment
60000
Start Date
2025-07
Completion Date
2028-11
Last Updated
2025-07-22
Healthy Volunteers
Yes
Conditions
Interventions
Prediction Model Arm
Lung cancer risk stratification via prediction model integrating: advanced age, lung cancer family history, personal cancer history, childhood coal exposure, asthma history, and food allergy history. High-risk individuals receive LDCT screening. Thoracic physicians guide management of screen-positive cases.
Standard Screening Arm
Participants are screened based on NCCN guideline criteria. High-risk individuals receive LDCT screening. Thoracic physicians guide management of screen-positive cases.