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Omega-3D: Omega-3 for Diet-Driven Health Disparities
Sponsor: University of Arizona
Summary
The goal of this clinical trial is to learn whether omega-3 fatty acid supplementation can reduce inflammation-related biomarkers and improve cardiovascular health in healthy adult volunteers with different genetic backgrounds. The main questions it aims to answer are: Does the response to omega-3 supplementation differ based on genetic variation in the FADS gene cluster (specifically rs174537)? Are changes in fatty acid ratios and inflammation markers greater among individuals of African ancestry compared to those of European ancestry? Researchers will compare omega-3 supplements to a placebo in a randomized, placebo-controlled crossover study to determine whether the Omega-3 supplementation is more effective in certain genetic and ancestry groups. Participants will take omega-3 supplements or a placebo daily for a defined period, then cross over to the other intervention. They will provide blood samples for analysis of fatty acid levels and inflammatory markers, complete questionnaires, and attend scheduled study visits.
Official title: Addressing Diet-Induced Health Disparities With Precision Nutrition and Omega-3 Fatty Acids
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-07-31
Completion Date
2029-12-31
Last Updated
2025-12-16
Healthy Volunteers
Yes
Interventions
Omega-3 Fatty Acids and Safflower Oil Placebo
Blinded study supplement; appearance-matched softgels.
Safflower Oil Placebo and Omega-3 Fatty Acids
Blinded study supplement; appearance-matched softgels.
Locations (2)
Arizona Cancer Center
Tucson, Arizona, United States
Georgetown University
Washington D.C., District of Columbia, United States