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RECRUITING

NCT07078500

PHASE2

Orelabrutinib Combined With Pola-R-CHP Regimen for the Treatment of Untreated Non-GCB Diffuse Large B-Cell Lymphoma

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

View on ClinicalTrials.gov

Summary

Assess the preliminary efficacy and safety of orelabrutinib in combination with the Pola-R-CHP regimen for the treatment of treatment-naive Non-GCB diffuse large B-cell lymphoma.

Official title: A Prospective, Single-Arm, Multicenter Clinical Study of Orelabrutinib Combined With Pola-R-CHP Regimen for the Treatment of Untreated Non-GCB Diffuse Large B-Cell Lymphoma

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

Start Date

2025-05-05

Completion Date

2028-12-31

Last Updated

2025-08-19

Healthy Volunteers

Conditions

Diffuse Large B-Cell Lymphoma (DLBCL)

Interventions

DRUG

orelabrutinib combined with the Pola-R-CHP regimen

Enrolled patients will receive six cycles of orelabrutinib in combination with the Pola-R-CHP regimen, with each 21-day period being one cycle. At the end of the six cycles, an interim efficacy evaluation will be conducted. Patients with a response of CR or PR will receive an additional two cycles of orelabrutinib in combination with rituximab and undergo a final efficacy evaluation. Patients with a response of CR/PR after eight cycles of induction therapy will receive maintenance treatment with orelabrutinib for up to two years.

Inclusion Criteria: 1. Age 18 to 80 years old. 2. Diffuse large B-cell lymphoma (DLBCL) confirmed by tumor tissue pathology, with at least one measurable lesion. 3. Non-GCB. 4. No prior anti-tumor treatment. 5. ECOG score of 0-2. 6. Life expectancy of ≥6 months. 7. Voluntary written informed consent. Exclusion Criteria: 1. Lymphoma involving the central nervous system or leptomeningeal metastasis. 2. Transformed lymphoma, that is, transformed from other types of lymphoma, such as follicular lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, or small B-cell lymphoma. 3. Primary mediastinal large B-cell lymphoma. 4. Burkitt lymphoma. 5. Laboratory values at screening (unless due to lymphoma): 1. Neutrophils \<1.5×10⁹/L; 2. Platelets \<75×10⁹/L; 3. ALT or AST more than 2 times the upper limit of normal, ALP and bilirubin more than 1.5 times the upper limit of normal; 4. Creatinine level more than 1.5 times the upper limit of normal. 6. Patients with psychiatric disorders or other known or suspected inability to fully comply with the study protocol. 7. Pregnant or breastfeeding women. 8. Known human immunodeficiency virus (HIV) infection, or active hepatitis B or C virus infection (positive result by polymerase chain reaction \[PCR\]). If the patient tests positive for HbsAg, HBV DNA testing is required. If HBV DNA \<10³ IU/ml, the patient may be enrolled. If the patient tests negative for HbsAg but positive for HBcAb (regardless of HBsAb status), HBV DNA testing is also required. If HBV DNA \<10³ IU/ml, the patient may be enrolled. If the patient tests positive for HCV antibody, HCV RNA is detected by PCR. If positive, the patient meets the exclusion criteria. 9. Need for continuous treatment with strong or moderate CYP3A inhibitors or CYP3A inducers. 10. Inability to swallow capsules or significant gastrointestinal disorders, such as malabsorption syndrome, bariatric surgery, inflammatory bowel disease, or partial or complete intestinal obstruction. 11. Other concurrent and uncontrolled medical conditions that the investigator believes will affect the patient's participation in the study.

Locations (1)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China