Clinical Research Directory

Inclusion Criteria: Experiment 1: Measurement Experiment of Remimazolam Blood Concentration and Dosage 1. Age 18-65 years old, ASAI-II class, BMI18.5-25kg/m\^2; 2. Inpatients undergoing laparoscopic cholecystectomy; 3. The estimated time of operation is 1.5\~2.5 hours; 4. Voluntary participation and signed informed consent. Experiment 2: Remimazolam metabolic enzyme CES1 activity measurement experiment 1. Age 18-75 years old, ASAI-III class; 2. Inpatients undergoing laparoscopic partial hepatic resection; 3. Voluntary participation and signed informed consent. Exclusion Criteria: Experiment 1:Measurement Experiment of Remimazolam Blood Concentration and Dosage 1. Pregnant or lactating women; 2. Patients who are allergic to remazolam or contraindicated; 3. Patients who are dependent on or tolerant to opioids or have long-term alcoholism; 4. Serious cardiovascular system, respiratory system, liver and kidney diseases; 5. History of obstructive sleep apnea; 6. Mental disorders or neurological diseases; 7. Patients who participated in clinical trials of other drugs within the last 3 months; 8. The attending physician or researcher considers that there are other circumstances that are not suitable for participation in this study; 9. Refuse to participate in the study Experiment 2: Remimazolam metabolic enzyme CES1 activity measurement experiment 1. Pregnant or lactating women; 2. Patients who are allergic to remazolam or contraindicated; 3. Patients who are dependent on or tolerant to opioids or have long-term alcoholism; 4. Serious cardiovascular system, respiratory system; 5. History of obstructive sleep apnea; 6. Mental disorders or neurological diseases; 7. Patients who participated in clinical trials of other drugs within the last 3 months; 8. The attending physician or researcher considers that there are other circumstances that are not suitable for participation in this study; 9. Refuse to participate in the study