Pre-operative Inclusion Criteria:
* Understand and be able to follow the requirements of the protocol including personally signing and dating an REB approved Informed Consent Form prior to undergoing any protocol related procedures
* Subjects aged 15 to 25 years with an ACL-deficient knee undergoing primary ACLR
* Subjects with skeletal maturity (i.e. closed epiphyseal growth plates on standard knee radiographs)
* At least two of the following factors that are associated with a high risk of graft failure:
1. participate in a competitive pivoting sport (defined as sports that include cutting and pivoting activities such as basketball, American football, soccer, lacrosse, volleyball, tennis/squash, handball, downhill skiing etc);
2. have a pivot shift of grade 2 or greater;
3. have generalized ligamentous laxity (Beighton score of \>= 4) and/or genu recurvatum \> 10 degrees
* Biological females have a negative pregnancy test within 4 days of initial surgery
* Is willing, able and likely to fully comply with clinical trial procedures and restrictions including follow-ups
Pre-operative Exclusion Criteria:
* Simultaneous bilateral ACLR
* Previous ACLR on either knee
* Less than one year from contralateral knee or contralateral/ipsilateral hip/ankle surgery
* Prior arthrotomy in the study knee
* Active infection anywhere or previous infection in the study knee
* History of peri-articular fracture in study knee
* \> 3 degrees of asymmetric varus or valgus
* The patient has debilitating knee pain that would preclude the use of QT tissue as a graft
* The patient has a significant quad tendonitis that would preclude the use of QT tissue as a graft
* Known or suspected allergy to brown seaweed, seaweed-based materials such as fucoidan, food allergies and/or presence of any allergy related dietary restrictions unless deemed by the investigator as "Not Clinically Significant"
* Known or suspected allergy to fucose, galactose, sulfur, sulfate, sulfite, or any sugar-based polymer or polysaccharides containing these
* Known hypersensitivity to sodium lactate or sulfur-containing compounds
* Any other severe allergic conditions or previous reactions (e.g., anaphylactic reactions, angioedema)
* Severe metabolic acidosis or alkalosis
* Have insulin dependent diabetes, severe diabetes and/or poorly controlled diabetes mellitus
* Any general medical or surgical condition that would preclude a standard knee ACLR
* Inflammatory arthropathy
* Breast feeding
* Have a medical condition that, in the opinion of the investigator would interfere with the evaluation of the safety or efficacy of the investigational product
* Have received any investigational products that, in the opinion of the investigator, would interfere with the evaluation of the safety or efficacy of the investigational product
* Have clinically relevant hemochromatosis, hepatic, renal, autoimmune, lymphatic, hematological or coagulation disorders
* Family history of blood or coagulation disorders
* History of heparin-induced thrombocytopenia (HIT) or known sensitivity to heparin-like products
Intra-operative Inclusion Criteria:
\- Patient undergoes primary anatomic anterior cruciate ligament reconstruction surgery with quadriceps tendon (QT) graft
Intra-operative Exclusion Criteria:
* Pre-existing arthrofibrosis in the knee
* Partial ACL rupture (defined as one bundle ACL tear requiring reconstruction/ augmentation of the torn bundle with no surgery required for the intact bundle) where ACLR is not performed
* Multiple ligament injury (two or more ligaments requiring surgery)
* Symptomatic articular cartilage defect requiring treatment other than debridement
* Articular cartilage lesion that requires any other surgical treatment apart from debridement
* Under anesthetic, this patient has a symmetrical or grade 1 pivot shift AND has a Beighton score \<4 AND \<10 degrees hyperextension
