Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
Sponsor: Hoffmann-La Roche
Summary
This multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for chronic weight management in adult participants with obesity or overweight with at least one weight-related comorbidity, but without diabetes mellitus.
Official title: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center, Phase II Study to Evaluate the Efficacy, Safety, and Tolerability of Once-Daily RO7795081 Administered for 38 Weeks to Participants With Obesity or Overweight With at Least One Weight-Related Comorbidity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
340
Start Date
2025-07-29
Completion Date
2026-07-17
Last Updated
2026-01-15
Healthy Volunteers
No
Conditions
Interventions
RO7795081
RO7795081 will be administered orally once daily, according to the randomized dosing regimen, during the 38-week treatment period.
Placebo
Placebo matching each RO7795081 dosing regimen arm will be administered orally once daily during the 38-week treatment period.
Locations (37)
Pinnacle Research Group
Anniston, Alabama, United States
Orange County Research Center
Lake Forest, California, United States
Prospective Research Innovations Inc.
Rancho Cucamonga, California, United States
Asclepes Research Centers
Sherman Oaks, California, United States
Encompass Clinical Research
Spring Valley, California, United States
Chase Medical Research
Waterbury, Connecticut, United States
Emerson Clinical Research Institute LLC
Washington D.C., District of Columbia, United States
K2 Medical Research-Winter Garden
Clermont, Florida, United States
K2 Medical Research - The Villages
Lady Lake, Florida, United States
K2 Medical Research-Maitland
Maitland, Florida, United States
Rophe Adult and Pediatric Medicine/SKYCRNG
Union City, Georgia, United States
Accellacare of Duly Health and Care
Oak Lawn, Illinois, United States
McFarland Clinic under Accellacare
Ames, Iowa, United States
Mercury Street Medical Group, PLLC
Butte, Montana, United States
Neurobehavioral Research, Inc.
Cedarhurst, New York, United States
Accellacare of Cary
Cary, North Carolina, United States
Accellacare - Hickory
Hickory, North Carolina, United States
Accellacare of Raleigh
Raleigh, North Carolina, United States
Accellacare of Rocky Mount
Rocky Mount, North Carolina, United States
Accellacare of Salisbury
Salisbury, North Carolina, United States
Accellacare of Piedmont Healthcare
Statesville, North Carolina, United States
Accellacare of Wilmington, LLC
Wilmington, North Carolina, United States
Accellacare Research of Winston Salem
Winston-Salem, North Carolina, United States
Alliance for Multispecialty Research, LLC (AMR Norman)
Norman, Oklahoma, United States
Tristar Clinical Investigations
Philadelphia, Pennsylvania, United States
Internal Medicine and Pediatrics Associates of Bristol
Bristol, Tennessee, United States
Alliance for Multispecialty Research. LLC
Knoxville, Tennessee, United States
Accellacare of Knoxville
Knoxville, Tennessee, United States
Knoxville-Summit-Halls Family Practice
Knoxville, Tennessee, United States
Clinical Research Associates
Nashville, Tennessee, United States
Texas Diabetes & Endocrinology, P.A.
Austin, Texas, United States
Apex Mobile Clinical Research
Bellaire, Texas, United States
Velocity Clinical Research
Dallas, Texas, United States
Juno Research, LLC
Houston, Texas, United States
Consano Clinical Research
Shavano Park, Texas, United States
Chrysalis Clinical Research
St. George, Utah, United States
Manassas Clinical Research Center
Manassas, Virginia, United States