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Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction
Sponsor: Alcon Research
Summary
This study is designed to see how safe and effective a new eye drop, called Reformulated PG324, is for lowering eye pressure in people with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Official title: A Phase III, Prospective, Double-Masked, Randomized, Multi-Center, Active-Controlled, Parallel Group Comparison Study Assessing the Ocular Hypotensive Efficacy of Reformulated PG324 Ophthalmic Solution in Subjects With Elevated Intraocular Pressure
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
489
Start Date
2025-09-02
Completion Date
2026-05
Last Updated
2026-01-13
Healthy Volunteers
No
Conditions
Interventions
Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution
Investigational ophthalmic solution
Netarsudil 0.02%/latanoprost 0.005% ophthalmic solution
Commercially available ophthalmic solution
Locations (30)
Trinity Research Group
Dothan, Alabama, United States
Eye Doctors of Arizona
Phoenix, Arizona, United States
Orange County Ophthalmology Medical Group
Garden Grove, California, United States
United Medical Research Institute
Inglewood, California, United States
Eye Research Foundation
Newport Beach, California, United States
North Bay Eye Associates
Petaluma, California, United States
Sacramento Eye Consultants
Sacramento, California, United States
Central Florida Eye Specialists
DeLand, Florida, United States
Glaucoma Specialists of South Florida
Delray Beach, Florida, United States
East Coast Institute for Research, LLC
Jacksonville, Florida, United States
Central Florida Eye Associates
Lakeland, Florida, United States
The Eye Institute of West Florida
Largo, Florida, United States
Lee Shettle Eye
Largo, Florida, United States
North Georgia Eye Associates
Gainesville, Georgia, United States
Coastal Research Associates
Roswell, Georgia, United States
Kannarr Eye Care LLC
Pittsburg, Kansas, United States
NorthEast Eye Research Associates, LLC
Westborough, Massachusetts, United States
Coldwater Vision Research
Coldwater, Mississippi, United States
Las Vegas Eye Institute
Henderson, Nevada, United States
Rochester Ophthalmological Group
Rochester, New York, United States
Albemarle Eye Center
Elizabeth City, North Carolina, United States
Oculus Research, Inc.
Garner, North Carolina, United States
CORE, Inc.
Shelby, North Carolina, United States
Midwest Eye Center
Cincinnati, Ohio, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Scott & Christie and Associates, PC
Cranberry Township, Pennsylvania, United States
Southern College of Optometry
Memphis, Tennessee, United States
Total Eye Care, PA
Memphis, Tennessee, United States
The Eye Institute of Utah
Salt Lake City, Utah, United States
Piedmont Eye Center
Lynchburg, Virginia, United States