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A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age
Sponsor: Centessa Pharmaceuticals (UK) Limited
Summary
Characterize the safety, tolerability and pharmacokinetics of ORX142 following single and multiple doses.
Official title: A Randomized, Double-blind, Sponsor-open, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single and Multiple Ascending Doses of ORX142 in Healthy Adults, Single Doses of ORX142 in Healthy Older Adults, and a Single Dose Crossover, Proof-of-concept Study of ORX142 in Acutely Sleep-deprived Healthy Subjects
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
208
Start Date
2025-06-30
Completion Date
2026-06-15
Last Updated
2025-12-24
Healthy Volunteers
Yes
Conditions
Interventions
ORX142 Tablets
ORX142 Tablets
Placebo Tablets
Placebo Tablets
Locations (3)
Site #1
Lincoln, Nebraska, United States
Site #2
Eatontown, New Jersey, United States
Site #3
New York, New York, United States