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RECRUITING
NCT07082829
PHASE1

A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years of Age

Sponsor: Centessa Pharmaceuticals (UK) Limited

View on ClinicalTrials.gov

Summary

Characterize the safety, tolerability and pharmacokinetics of ORX142 following single and multiple doses.

Official title: A Randomized, Double-blind, Sponsor-open, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single and Multiple Ascending Doses of ORX142 in Healthy Adults, Single Doses of ORX142 in Healthy Older Adults, and a Single Dose Crossover, Proof-of-concept Study of ORX142 in Acutely Sleep-deprived Healthy Subjects

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

208

Start Date

2025-06-30

Completion Date

2026-06-15

Last Updated

2025-12-24

Healthy Volunteers

Yes

Interventions

DRUG

ORX142 Tablets

ORX142 Tablets

OTHER

Placebo Tablets

Placebo Tablets

Locations (3)

Site #1

Lincoln, Nebraska, United States

Site #2

Eatontown, New Jersey, United States

Site #3

New York, New York, United States