Clinical Research Directory

Inclusion Criteria: * Adult (55+) * History of skin tears, at least 2 in the past month * History of skin bruising (solar purpura) * Ambulatory * Able to apply topical medication to oneself Exclusion Criteria: * \<55 years old) * Pregnant or breastfeeding * History of allergy to tretinoin * History of atopic dermatitis, psoriasis, bullous skin disease, cutaneous lupus, or cutaneous T cell lymphoma. * Planned cutaneous surgery on either forearm in the next 6 months * Use of any topical medication on the forearms within past month * Current or anticipated phototherapy of the forearms in the next 6 months * Current or anticipated chemotherapy within the next 6 months * Use of oral steroids within past month * Current or prior isotretinoin therapy within past 6 months * AV fistula of the arm