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Comparison of Outcomes of Management of Bowel Obstruction
Sponsor: University of Washington
Summary
The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
550
Start Date
2026-02
Completion Date
2030-12
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
Dexamethasone
\*Please see description for dexamethasone + supportive care arm.
Supportive Care
\*Please see description for supportive care arm.
Locations (3)
Harborview Medical Center
Seattle, Washington, United States
UW Medical Center - Northwest
Seattle, Washington, United States
University of Washington Medical Center Montlake
Seattle, Washington, United States