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RECRUITING
NCT07084441
PHASE4

Comparison of Outcomes of Management of Bowel Obstruction

Sponsor: University of Washington

View on ClinicalTrials.gov

Summary

The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

550

Start Date

2026-02

Completion Date

2030-12

Last Updated

2026-02-19

Healthy Volunteers

No

Interventions

DRUG

Dexamethasone

\*Please see description for dexamethasone + supportive care arm.

OTHER

Supportive Care

\*Please see description for supportive care arm.

Locations (3)

Harborview Medical Center

Seattle, Washington, United States

UW Medical Center - Northwest

Seattle, Washington, United States

University of Washington Medical Center Montlake

Seattle, Washington, United States