Clinical Research Directory

Inclusion Criteria: * At least 18 years of age * Individuals diagnosed with cardiovascular-kidney-metabolic (CKM) syndrome stages 0 to 3 according to the American Heart Association (AHA) or liver disease defined by any of the following: * For stage 0: Individuals without overweight/obesity, metabolic risk factors (normoglycemia, normotension, normal lipid profile), Chronic kidney disease (CKD), or Cardiovascular disease (CVD) * Individuals with overweight/obesity or dysfunctional adipose tissue, without other metabolic risk factors or CKD * Individuals with metabolic risk factors (hypertriglyceridemia, arterial hypertension, metabolic syndrome, diabetes) or CKD * Subclinical Atherosclerotic cardiovascular disease (ASCVD) or subclinical heart failure (HF) in individuals with excess/dysfunctional adiposity, other metabolic risk factors, or CKD in the clinical assessment\[2\] * Independent of CKM syndrome stages, individual with signs of hepatic steatosis on imaging * Willingness to provide informed consent Exclusion Criteria: * Individuals with CKM syndrome stage 4 according to the AHA \* Individuals with clinical cardiovascular disease including: * History of coronary artery disease, myocardial infarction, coronary artery intervention * History of atrial fibrillation * History of stroke * Symptomatic peripheral artery disease (\>stage I) * History of symptomatic HF * History of HF hospitalisation * Inability to sign informed consent