Clinical Research Directory

Inclusion Criteria: Parts 1 and 2 * Age 18-65 * Must be in good health with no significant medical history * Willing and able to attend all study visits and comply with study requirements, including lumbar puncture for CSF collection * Able and willing to provide written informed consent Part 3 * Age 18-60 * Must be in good health with no significant medical history * MS diagnosis prior to Day 1 in accordance with 2017 McDonald criteria. * Willing and able to attend all study visits and comply with study requirements, including lumbar puncture for CSF collection * Able and willing to provide written informed consent Exclusion Criteria: * Evidence of clinically significant condition or disease * Any physical or psychological condition that prohibits study completion * Known history of illicit drug use or drug abuse, harmful alcohol use (at the -Investigator's discretion), alcoholism, and/or smoking or nicotine-containing product use within 7 days prior to the first dose of study agent * History of severe allergic reactions or hypersensitivity * Donation or loss of ≥ 1 unit of whole blood or plasma within 4 weeks prior to dosing