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A Study to Learn About How a New Pneumococcal Vaccine Works in Adults
Sponsor: Pfizer
Summary
The purpose of this study is to learn about the safety and tolerability of a pneumococcal vaccine in adults. Participants will receive either: * an experimental PG4 vaccine * a PG4 vaccine comparator * a standard 20vPnC vaccine comparator * placebo. A placebo does not have any medicine in it but looks just like the study medicine. Participants will take part in this study for up to 18 months depending on which group they are assigned to. During this time, the participants will receive up to two doses of study vaccine or comparator and take part in follow-up visits. At these clinic visits, participants will be asked if any side effects were experienced. The participants will also have to give blood samples during clinic visits.
Official title: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN STUDY TO DESCRIBE THE SAFETY AND TOLERABILITY OF A MULTIVALENT PNEUMOCOCCAL CONJUGATE VACCINE IN ADULTS
Key Details
Gender
All
Age Range
65 Years - 84 Years
Study Type
INTERVENTIONAL
Enrollment
380
Start Date
2025-07-22
Completion Date
2027-10-21
Last Updated
2026-04-08
Healthy Volunteers
Yes
Conditions
Interventions
PG4 vaccine in Buffer 1 with low dose PA-001
Multivalent pneumococcal conjugate vaccine
PG4 in Buffer 1 with low dose PA-002
Multivalent pneumococcal conjugate vaccine
PG4 in Buffer 1 with high dose PA-001
Multivalent pneumococcal conjugate vaccine
PG4 vaccine in Buffer 1 with high dose PA-002
Multivalent pneumococcal conjugate vaccine
PG4 vaccine in Buffer 2
Multivalent pneumococcal conjugate vaccine
20-valent pneumococcal conjugate vaccine
(20vPnC)
Saline injection
Placebo
Locations (19)
Orange County Research Center
Lake Forest, California, United States
Peninsula Research Associates
Rolling Hills Estates, California, United States
Finlay Medical Research
Greenacres City, Florida, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Johnson County Clinical Trials
Lenexa, Kansas, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO
Springfield, Missouri, United States
Bio-Kinetic Clinical Applications, LLC dba QPS-MO-Screening and Recruitment Center
Springfield, Missouri, United States
Velocity Clinical Research, Omaha
Omaha, Nebraska, United States
Upstate Global Health Institute
East Syracuse, New York, United States
NYU Langone Health
New York, New York, United States
Duke Vaccine and Trials Unit
Durham, North Carolina, United States
CTI Clinical Research Center
Cincinnati, Ohio, United States
Headlands Horizons, LLC dba Headlands Research-Brownsville
Brownsville, Texas, United States
Valley Regional Medical Center
Brownsville, Texas, United States
LabCorp
Houston, Texas, United States
IMA Clinical Research San Antonio
San Antonio, Texas, United States
Dynamed Clinical Research, LP d/b/a DM Clinical Research
Tomball, Texas, United States
J. Lewis Research, Inc. / Foothill Family Clinic
Salt Lake City, Utah, United States
J. Lewis Research, Inc. / Foothill Family Clinic South
Salt Lake City, Utah, United States