Clinical Research Directory

Inclusion Criteria: * Healthy subjects with ASA health score of I or II * Subjects aged between ≥ 18 and ≤ 65 years. * Subjects who have provided informed consent and are willing to comply with the study procedures. Exclusion Criteria: * Heavy smokers or individuals exposed to high levels of carbon monoxide resulting in elevated carboxyhemoglobin levels. * Individuals with conditions that result in elevated methemoglobin levels. * Individuals with hypoxia (SpO2 \< 95% at 21% O2). * Severe claustrophobia. * Subjects known with altitude sickness. * Subjects who are obese (BMI ≥ 35 kg/m2). * Subjects with a known history of moderate to severe heart, lung, kidney or liver disease. * Subjects diagnosed with moderate to severe asthma. * Subjects with a hemoglobinopathy or history of anemia, e.g. sickle cell anemia, thalassemia, that in the investigator's opinion, would make them unsuitable for study participation. * Subjects with any other serious systemic illness. * Any injury, deformity, or abnormality at the sensor sites that, in the investigator's opinion, would interfere with the correct functioning of the test or reference devices. * Subjects with a history of fainting or vasovagal response. * Subjects with a history of sensitivity or allergy to local anesthetics or disinfectants if included in the IN study. * Subjects diagnosed with Raynaud's disease. * Subjects with unacceptable collateral circulation based on examination by the investigator. * Subjects who are pregnant, lactating or trying to become pregnant. * Subjects unable or unwilling to provide informed consent or comply with study procedures. * Subjects with any other condition that, in the investigator's opinion, would make them unsuitable for the study. * Subjects who refuse to remove nail polish from their index finger. * Volunteers not willing to remove facial make-up.