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Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Sponsor: Chang Gung Memorial Hospital
Summary
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
Official title: Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2025-09-01
Completion Date
2028-09-01
Last Updated
2025-08-14
Healthy Volunteers
No
Interventions
Gamma auditory stimulation device (active setting)
Participants will receive auditory stimulation using the gamma auditory stimulation device (active setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.
Gamma auditory stimulation device (sham setting)
Participants will receive auditory stimulation using the gamma auditory stimulation device (sham setting) for 1 hour per day, 5 days a week, over 12 weeks, for a total of 60 hours.
Locations (1)
Chang Gung University
Taoyuan District, Guishan, Taiwan