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Triggering Ovulation at Follicle Size Smaller or Larger Than 17mm in a Modified Natural Cycle
Sponsor: Vida Recoletas Sevilla
Summary
The rise in frozen embryo transfer (FET) cycles within assisted reproductive technology (ART) has sparked the need to refine endometrial preparation protocols. The switch from hormone replacement cycles (HRT) to natural cycles, poses scheduling challenges onto laboratories, doctors and patients. The modified natural cycle (mNC), offering more precision for scheduling, shows promise but lacks comprehensive data on the potential flexibility of triggering criteria that may allow to control timing in a wider range. This prospective randomized study seeks to address this knowledge gap by evaluating the non-inferiority of triggering ovulation in mNC with follicle diameters of 13-16.9mm compared to the conventional 17-22mm. The study aims to enhance the understanding of the impact of follicle size at ovulation in reproductive outcomes, optimize FET treatments providing a more flexible mNC protocol, and improve patient care in ART clinics.
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
572
Start Date
2025-10-22
Completion Date
2028-05-30
Last Updated
2026-01-13
Healthy Volunteers
No
Conditions
Interventions
Trigger at smaller folicular size
Trigger indicated at folicular diameter smaller than standard clinical practice, from 13mm to 16.9mm
Locations (1)
Vida Recoletas Sevilla
Seville, Sevilla, Spain