Clinical Research Directory

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * With the exception of type 2 diabetes mellitus (T2DM), is in generally good health * Has a history of T2DM for ≥1 year at the time of screening based on self-reporting * Has a baseline HbA1C level of ≤10% at the time of screening * Has a stable weight (based on self-reporting) defined as ≤5 kg gain or loss of body weight for at least 3 months before Visit 1/Screening * T2DM treated with lifestyle modification alone or with stable doses (no significant change for ≥3 months from Visit 1/Screening, based on self-reporting) of ≤ 3 oral anti-diabetic medications and anticipated not to require dose adjustments during the study duration * Body mass index (BMI) between 25 and 40 kg/m2, inclusive Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has known systemic hypersensitivity to the MK-2828 drug substance or other nucleotide-binding, leucine-rich, protein 3 inhibitor (NLRP3i) based therapy, its inactive ingredients, or the placebo * Has a history of congestive heart failure (New York Heart Association \[NYHA\] Class 3 or 4) * Has a history of myocardial infarction, uncontrolled arrhythmias, cardiac revascularization, unstable peripheral arterial disease and/or stroke within 6 months of screening * History of significant multiple and/or severe allergies (e.g., food, drug, latex allergy), or has had an anaphylactic reaction or significant intolerability (i.e., systemic allergic reaction) to prescription or nonprescription drugs or food * Has type 1 diabetes mellitus or secondary types of diabetes * Has experienced complications of diabetes such as ketoacidosis, unstable diabetic retinopathy, or maculopathy * Has previous or planned (during the trial period) obesity treatment with surgery or a weight loss device