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Evaluation of The Periodontal Parameters Following Non-Surgical Periodontal Therapy With and Without Adjunctive Use of Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial
Sponsor: Cairo University
Summary
This randomized controlled clinical trial aims to evaluate the effectiveness of non-surgical periodontal therapy (NSPT) with and without the adjunctive use of injectable platelet-rich fibrin (I-PRF) in patients with chronic periodontitis. The primary objective is to assess changes in key periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index (PI) over a defined follow-up period. Participants will be randomly assigned to two groups: one receiving standard NSPT alone and the other receiving NSPT combined with subgingival application of I-PRF. The study seeks to determine whether the adjunctive use of I-PRF can enhance periodontal healing and improve clinical outcomes compared to conventional therapy alone.
Key Details
Gender
All
Age Range
Any - 70 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-07
Completion Date
2025-10
Last Updated
2025-07-29
Healthy Volunteers
Yes
Conditions
Interventions
non-surgical periodontal therapy
Mechanical Root Instrumentation using Ultrasonic scaling and root debridement using Gracey Curettes
non-surgical periodontal therapy + I-PRF
Mechanical Root Instrumentation using Ultrasonic scaling and root debridement using Gracey Curettes following by subgingival application of I-PRF
Locations (1)
Gulf Medical University
Ajman, Ajman Emirate, United Arab Emirates