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A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Sponsor: Pfizer
Summary
The purpose of the study is to explore the safety and effects of the study drug (PF-08046876) in people diagnosed with advanced cancer of the bladder, lung, head and neck, esophagus, or pancreas. PF-08046876 is an investigational anticancer therapy called an 'antibody drug conjugate' or 'ADC'. ADCs are anticancer drugs designed to stick to cancer cells and kill them. The study drug will be given to participants through a needle in a vein (intravenous infusion). This study includes multiple parts. In the first part of the study, there will be different groups of people receiving different doses of the study drug. The study may also test different schedules.
Official title: A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
310
Start Date
2025-08-20
Completion Date
2029-07-08
Last Updated
2026-04-07
Healthy Volunteers
No
Conditions
Interventions
PF-08046876
Intravenous administration
Locations (28)
City of Hope National Medical Center
Duarte, California, United States
City of Hope at Irvine Lennar
Irvine, California, United States
Ronald Reagan UCLA Medical Center
Los Angeles, California, United States
UCLA Department of Medicine-Hematology/Oncology
Los Angeles, California, United States
Santa Monica UCLA Medical Center & Orthopaedic Hospital
Santa Monica, California, United States
UCLA Hematology/Oncology - Santa Monica
Santa Monica, California, United States
Smilow Cancer Hospital - Yale New Haven Health
New Haven, Connecticut, United States
Yale - New Haven Hospital - Yale Cancer Center
New Haven, Connecticut, United States
Smilow Cancer Hospital Phase 1 Unit
New Haven, Connecticut, United States
Smilow Cancer Hospital - Trumbull
Trumbull, Connecticut, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Dana-Farber Cancer Institute - Chestnut Hill
Newton, Massachusetts, United States
Sarah Cannon Research Institute - Pharmacy
Nashville, Tennessee, United States
SCRI Oncology Partners
Nashville, Tennessee, United States
The University of Texas MD Anderson Cancer Center - Conroe
Conroe, Texas, United States
University of Texas MD Anderson Cancer Center
Houston, Texas, United States
The University of Texas, MD Anderson Cancer Center - West Houston
Houston, Texas, United States
The University of Texas, MD Anderson Cancer Center - League City
League City, Texas, United States
NEXT Oncology
San Antonio, Texas, United States
The University of Texas, MD Anderson Cancer Center - Sugar Land
Sugar Land, Texas, United States
Princess Margaret Cancer Centre
Toronto, Ontario, Canada
Pan American Center for Oncology Trials, LLC
Rio Piedras, Puerto Rico
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [barcelona], Spain
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Barts Cancer Centre at St. Bartholomew's Hospital; Queen Mary University of London
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom