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Molecular Transcriptomics in Diagnosing Pediatric Kidney Transplant Rejection: the PANDA-Kids-ATLAS Study
Sponsor: Paris Translational Research Center for Organ Transplantation
Summary
Children with kidney failure have markedly increased mortality and face repeated transplantation over their lifetime due to limited allograft half-life (12-15 years). Current biopsy-based diagnoses of rejection (using Banff 2022 criteria) suffer from variability and limited sensitivity. PANDA-Kids-ATLAS will analyze up to 600 pediatric FFPE kidney biopsies across multiple centres using the Banff Human Organ Transplant (B-HOT) NanoString panel to develop and validate molecular classifiers of AMR, TCMR and related phenotypes. A secure REDCap database will integrate molecular, pathological and clinical data, aiming to improve early detection, personalize therapy, and enhance long-term graft survival and patient quality of life.
Official title: Precision Allograft Rejection Using Novel Diagnostic Approaches in Kidney Transplantation - Allograft Transcriptomics Landscape Analysis Using Sequencing (the PANDA-Kids-ATLAS Study)
Key Details
Gender
All
Age Range
0 Years - 21 Years
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2025-09-01
Completion Date
2028-12-31
Last Updated
2025-07-29
Healthy Volunteers
Yes
Conditions
Locations (1)
Paris Institute for Transplantation and Organ Regeneration (PITOR)
Paris, France