Clinical Research Directory

Inclusion Criteria 1. Subjects must voluntarily agree to participate in the clinical trial and sign a written informed consent form (ICF) before undergoing any trial-related procedures. 2. Male or female subjects aged ≥18 and ≤75 years at the time of signing the informed consent. 3. Histologically confirmed adenocarcinoma of the stomach or gastroesophageal junction with signet ring cell components. Diagnosis of locally advanced disease (based on AJCC 8th edition) must be made within 4 weeks prior to randomization. 4. Tumor staging: cT3-4a or cN+ (M0) as determined by endoscopic ultrasound and/or contrast-enhanced CT/MRI. Diagnostic laparoscopy may be used as needed. The tumor must be assessed as resectable by the investigator. 5. Immunohistochemical testing confirms proficient mismatch repair (pMMR) status and HER-2 negativity (IHC 0 or 1+, or IHC 2+ with negative FISH for HER-2 amplification). 6. No prior systemic treatment for the current malignancy, including surgery, chemotherapy, radiotherapy, or immunotherapy. 7. Eligible for radical surgery with no surgical contraindications as determined by a qualified surgeon. 8. ECOG performance status of 0 or 1 within 7 days before randomization. 9. Estimated life expectancy \> 6 months. 10. Adequate organ function, as demonstrated by the following laboratory results (without blood product transfusion or cytokine support within 2 weeks prior to first dose): Hematologic: WBC ≥ 3.5 × 10⁹/L, ANC ≥ 1.5 × 10⁹/L, Platelets ≥ 100 × 10⁹/L, Hemoglobin ≥ 90 g/L Hepatic: Total bilirubin ≤ 1.5 × ULN, AST and ALT ≤ 2.5 × ULN Renal: Serum creatinine ≤ 1.0 × ULN, Creatinine clearance ≥ 60 mL/min (Cockcroft-Gault formula) Coagulation: INR, APTT, PT ≤ 1.5 × ULN Thyroid: TSH within normal limits. If TSH is abnormal, subjects with normal total T3 (or FT3) and FT4 may be enrolled. Cardiac: Left ventricular ejection fraction (LVEF) ≥ 50% by echocardiogram; cardiac assessment may be required for patients with cardiac comorbidities. Hepatitis B serology: HBsAg (-) and anti-HBc (-). If HBsAg (+) or anti-HBc (+), HBV-DNA must be \<1000 copies/mL or \<200 IU/mL or below the site-specific ULN. HCV antibody (-). Subjects with positive HCV antibody but negative HCV-RNA may be considered eligible. 11\) For women of childbearing potential: Negative serum or urine pregnancy test within 7 days before randomization. If urine test is inconclusive, a serum test is required. Postmenopausal status is defined as ≥12 months of amenorrhea or surgical sterilization (bilateral oophorectomy/hysterectomy). 12\) Subjects (regardless of sex) with reproductive potential must agree to use highly effective contraception (failure rate \<1%) from the start of study treatment to 120 days after last study dose (or 180 days if receiving chemotherapy). 13\) Breastfeeding is not permitted during the study period. Exclusion Criteria 1. Histology other than adenocarcinoma with signet ring cell features, including squamous cell carcinoma, neuroendocrine carcinoma, or other subtypes. 2. Tumor exhibiting deficient MMR (dMMR) or HER-2 positivity (IHC 3+, or IHC 2+ with FISH-confirmed HER-2 amplification). 3. Unresectable tumors or subjects unwilling or unable to undergo surgery due to medical, anatomical, or personal reasons. 4. History of other malignancies within 5 years prior to enrollment, excluding certain cured cancers (e.g., basal cell carcinoma, carcinoma in situ of cervix/breast/prostate/bladder). 5. Evidence of active bleeding on endoscopy. 6. Participation in another interventional clinical study or use of investigational drugs/devices within 4 weeks prior to enrollment. 7. Prior immunotherapy including immune checkpoint inhibitors (e.g., anti-PD-1/PD-L1, anti-CTLA-4, anti-TIGIT, etc.) or cellular immunotherapy. 8. Use of traditional Chinese medicine with antitumor or immunomodulatory effects within 2 weeks prior to first dose. 9. Active autoimmune disease requiring systemic therapy in the last 2 years. Hormonal replacement therapies are allowed. 10. Use of systemic corticosteroids or immunosuppressants within 7 days before first dose (except ≤10 mg/day prednisone equivalent). 11. Prior or planned organ/bone marrow transplantation (excluding corneal transplant). 12. Known hypersensitivity to investigational products. 13. Conditions affecting oral administration of capecitabine (e.g., dysphagia, intestinal obstruction). 14. HIV infection (HIV-1/2 antibody positive). 15. Active hepatitis B (HBsAg positive and HBV DNA \> ULN). 16. Active hepatitis C (HCV antibody positive with detectable HCV RNA). 17. Receipt of live vaccines within 30 days prior to first dose. Inactivated influenza vaccines are permitted; live attenuated intranasal influenza vaccine is not. 18. Pregnant or breastfeeding women. 19. Serious or uncontrolled systemic illnesses, including: Significant arrhythmias or heart block History of myocarditis, cardiomyopathy, MI, unstable angina, CHF within 12 months Gastrointestinal conditions (e.g., active ulcers, varices, perforation, abscess) within 6 months Recent COPD exacerbation (within 1 month) Grade ≥3 thromboembolic events or cerebrovascular accidents within 6 months Poorly controlled hypertension (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg despite treatment) Non-infectious pneumonitis or interstitial lung disease Pulmonary tuberculosis Active systemic infection Decompensated liver disease Poorly controlled diabetes (FBG \>10 mmol/L or random BG \>16 mmol/L) Proteinuria ≥ ++ or 24-hour urine protein \> 1.0 g 20. Psychiatric illness interfering with compliance or safety. 21. Major surgery or significant trauma within 30 days prior to first dose, or planned major surgery within 30 days post first dose (except minor procedures). 22. Tumor necrosis on imaging, deemed high risk for bleeding by investigator. 23. History of severe bleeding or coagulation disorders; active bleeding within 1 month (e.g., hematemesis, hemoptysis, significant epistaxis); long-term anticoagulation for atrial fibrillation with CHADS2 ≥ 2. 24. Any condition or laboratory abnormality that, in the opinion of the investigator, may interfere with the study results or subject safety.