Clinical Research Directory

Inclusion Criteria: * Age \> 18 years and \< 80 years * Presented as asymptomatic angina, stable angina, unstable angina, prior myocardial infarction (MI), or non-ST-elevation myocardial infarction (NSTEMI). * Have an indication for drug-eluting stent (DES) implantation * Denovo coronary artery calcified lesions * Target lesion diameter stenosis ≥ 70%, or target lesion diameter stenosis between ≥ 50% and \< 70%, accompanied by evidence of myocardial ischemia(such as fractional flow reserve (FFR) ≤ 0.80 or minimal lumen area (MLA) ≤ 4.0 mm²). * Reference vessel diameter of the target vessel between 2.5 mm - 4.5 mm * Maximum calcium arc within the lesion ≥ 270⁰ assessed by optical coherence tomography (OCT) or intravascular ultrasound (IVUS) * Unsatisfactory lesion preparation with non-compliant balloon, defined as baseline diameter stenosis reduction of \< 30% under maximal inflation pressure. * Provision of written informed consent Exclusion Criteria: * Presented as acute ST-segment elevation myocardial infarction (STEMI), cardiogenic shock and multiple organ failure * Presented as severe contrast agent allergy * Intolerant to dual antiplatelet therapy (DAPT) and/or anticoagulation therapy * Presented as active phase of autoimmune disease * Calcified nodules or eccentric calcification lesions * Failure to reach the target lesion with guidewires or catheters * Complex coronary bifurcation lesions * Target vessel thrombosis or aneurysm within 10 mm of the target lesion