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Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.
Sponsor: IRCCS Eugenio Medea
Summary
Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG). The aim is to identify neurophysiological biomarkers and analyze the relationship between cortical connectivity, cognitive functioning, and clinical severity, particularly in response to rehabilitation treatment.
Official title: Structural-Functional Connectome and High Density Electroencephalogram: Pilot Study in Patients With Friedreich's Ataxia.
Key Details
Gender
All
Age Range
8 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-07-07
Completion Date
2026-12-31
Last Updated
2025-07-31
Healthy Volunteers
No
Conditions
Interventions
HD-EEG recordings, combined with cognitive and motor assessment
Participants will undergo high-density EEG (HD-EEG) recordings under two conditions: at rest and while performing an upper limb motor task. The data obtained will be used to reconstruct source cortical activity and derive patterns of functional connectivity, using advanced neurophysiological analysis techniques, including the Avalanche Transition Matrix (ATM). In addition, patients will complete a neuropsychological assessment and participate in an intensive multidisciplinary rehabilitation program lasting 3 to 4 weeks, depending on age. The intervention aims to assess changes in the functional organization of the brain before and after treatment, as well as one year later, in order to explore potential biomarkers of disease progression.
Locations (1)
IRCCS Eugenio Medea / Associazione la Nostra Famiglia
Conegliano, Treviso, Italy