Clinical Research Directory

Inclusion Criteria: * U.S. men and women meeting the age of majority, defined as follows: Age 19 or older in Nebraska and Alabama. Age 21 or older in Puerto Rico. Age 18 or older in all other states. * Able and willing to travel to Washington DC for a dual-energy х-rау absorptiometry (DXA) scans before and after the program. * Able and willing to complete laboratory assessments at a local LabCorp facility before and after the program. * Able and willing to participate in all components of the study. * BMI of 25 or more (23 or more in persons of Asian origin). * Access to the internet. * English fluency. Exclusion Criteria: * Use of recreational drugs in the past 6 months. * Pregnancy or intention to become pregnant during the study period, as verified by self-report. * Unstable medical or psychiatric illness. * Inability to maintain medication regimen as prescribed by personal healthcare provider. * Current or expected use of any weight loss medication during the study period, including but not limited to, glucagon-like peptide-1 (GLP-1) receptor agonists and combination GLP-1 receptor/glucose-dependent insulinotropic polypeptide (GIP) agonists. * Use of any weight loss medication within the 12 months preceding the study period, including but not limited to, glucagon-like peptide-1 (GLP-1) receptor agonists and combination GLP-1 receptor/glucose-dependent insulinotropic polypeptide (GIP) agonists. * Body weight greater than 182 kg. * Current diagnosis of eating disorder. * Intention to follow another weight loss method during the study period.