Clinical Research Directory

Inclusion Criteria: 1. Age: 18-80 years old. 2. Acute mild non-cardioembolic stroke. 3. NIHSS score ≤5. 4. Time from onset to randomization of ≤48 hours; if the time of onset is unknown, time from the last known time of being well to randomization of ≤48 hours. 5. The investigational drug can be administered within 48 hours of symptom onset. 6. Signed informed consent by the patient or legally authorized representative. Exclusion Criteria: 1. Received or planned to receive intravenous thrombolysis or bridging therapy (with subsequent endovascular treatment) 2. Intracranial hemorrhage confirmed by imaging. 3. Pre-stroke modified Rankin Scale (mRS) score ≥2. 4. Any confirmed cardioembolic source, including chronic or paroxysmal atrial fibrillation, sick sinus syndrome, mitral stenosis, mechanical heart valve, infective endocarditis, intracardiac thrombus or vegetation, myocardial infarction within 3 months, dilated cardiomyopathy, left atrial spontaneous echo contrast, ejection fraction \<30%. 5. History of primary intracerebral hemorrhage. 6. History of other intracranial hemorrhage (intraventricular, subarachnoid, epidural, or subdural hemorrhage). 7. Untreated or inadequately treated intracranial aneurysm or vascular malformation. 8. Major systemic bleeding within 30 days. 9. Active bleeding, including laboratory evidence of coagulopathy (platelet count \<100 × 10⁹/L, activated partial thromboplastin time \>50 seconds, or international normalized ratio \>1.7), or treatment with direct oral anticoagulants within the preceding 48 hours. 10. Major surgery within 14 days. 11. Persistently elevated blood pressure (systolic \>180 mmHg or diastolic \>110 mmHg) despite treatment. 12. Baseline platelet count \<100 × 10⁹/L. 13. Severe renal dysfunction (glomerular filtration rate \<30 mL/min or serum creatinine \>220 μmol/L \[2.5 mg/dL\]). 14. Known allergy or contraindication to tirofiban or aspirin. 15. Current pregnancy or lactation. 16. Any intracranial tumor (except asymptomatic meningiomas ≤1.5 cm in diameter). 17. Any terminal illness with life expectancy \<6 months.