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The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock
Sponsor: Avicenna Military Hospital
Summary
The ratio of the venous-arterial carbon dioxide partial pressure difference to the arteriovenous oxygen content difference (Pv-aCO₂/Ca-vO₂) may be a marker of anaerobic metabolism in patients with acute circulatory failure. This study aims to assess the prognostic value of the PvCO2-PaCO2/CaO2-CvO2 in the early phase of septic shock.
Official title: Prognostic Value and Kinetics of the PvCO2-PaCO2/CaO2-CvO2 Ratio Compared to Arterial Lactate in the Initial Phase of Septic Shock
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2025-01-05
Completion Date
2026-06-30
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Interventions
PvCO2-PaCO2/CaO2-CvO2 ratio
Patients diagnosed with septic shock will undergo serial measurements of arterial and venous blood gas analyses, arterial lactate levels, and calculation of the Pv-aCO₂/Ca-vO₂ ratio at predefined time points: H0 (baseline), H2, H6, H12, and H24. Calculation Formulas: 1. Arterial Oxygen Content (CaO₂):CaO2 = SaO2 × Hb × 1,34 + PaO2 × 0,0031 2. Venous Oxygen Content (CvO₂):CvO2 = SvO2 × Hb × 1,34 + PvO2 × 0,0031 3. Pv-aCO₂/Ca-vO₂ Ratio: P(v-a) CO2/C(a-v)O2=(PcvCO2-PaCO2)/(CaO2 -CcvO2).
Locations (3)
Avicenna Military Hospital
Marrakesh, Marrakesh, Morocco
Avicenna Military Hospital
Marrakesh, Morocco
Department of critical care Medicine. Avicenna Military Hospital
Marrakesh, Morocco