Clinical Research Directory

Inclusion Criteria: * Age 18-75 years old, ASA Ⅰ - Ⅱ (the age of patients with vitreous surgery can be relaxed to 75 years old, and serious systemic diseases need to be excluded); * Vitrectomy with local anesthesia (retrobulbar / peribulbar block) combined with intravenous sedation and analgesia (such as maculopathy, retinal detachment, etc.); * Preoperative VAS score ≤ 3, can cooperate with pain and sedation score; * Signed informed consent. Exclusion Criteria: * Be allergic to test drugs or opioids, or have a history of opioid abuse; * Severe cardiopulmonary disease (such as heart failure, COPD), liver and kidney dysfunction (alt/ast \> 3 times normal, creatinine \> 177 μ mol/l); * Glaucoma (avoiding the risk of fluctuation of intraocular pressure), sinus bradycardia (\< 50 beats / min, preventing aggravation of oculo cardiac reflex); * Used analgesic / sedative drugs within 24 hours before surgery; * Those who are unable to cooperate due to mental illness or cognitive impairment.