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Determinants of the Response to BTK Degraders (BTKd) in Double Refractory CLL
Sponsor: Nantes University Hospital
Summary
The aim of the REBELLE cohort - bio-collection is to collect samples from patients with Chronic Lymphocytic Leukemia (CLL), to facilitate access for the National Institute of Health and Medical Research (INSERM) to patients with double-refractory CLL. To do this, an additional blood or bone marrow sample to those planned in the context of patient care or a residual lymph node biopsy sample will be collected after signing consent. These samples will first be sent to the Filothèque for temporary storage, and will then be transferred to CRCI²NA (Nantes - Angers Cancer and Immunology Research Center) for analysis with the aim of studying the mechanisms of resistance and response to BTK degraders (BTKd).
Official title: Determinants of the Response to BTK Degraders (BTKd) in Double Refractory Chronic Lymphocytic Leukemia (CLL)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2025-10-09
Completion Date
2039-09-15
Last Updated
2025-12-09
Healthy Volunteers
No
Interventions
Non-Interventional Sample Collection and Analysis
This study is observational. Biological samples are collected as part of standard care or for research purposes and analyzed to characterize resistance mechanisms. No treatment or intervention is administered as part of the study protocol.
Locations (14)
CHU de Angers
Angers, France
CHU de Bordeaux
Bordeaux, France
Institut Bergonié
Bordeaux, France
CHU de Clermont-Ferrand
Clermont-Ferrand, France
CHD Vendée
La Roche-sur-Yon, France
Centre Léon Bernard
Lyon, France
Institut Paoli-Calmettes (Marseille)
Marseille, France
CHU de Montpellier
Montpellier, France
CH Régional Universitaire de Nancy
Nancy, France
University Hospital
Nantes, France
Hôpital Avicenne (AP-HP)
Paris, France
Hôpital Universitaire Pitié Salpêtrière de Paris
Paris, France
CHU de Poitiers
Poitiers, France
Centre Henri-Becquerel de Rouen
Rouen, France