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Bacteria in Dental Plaque and Atheroma Plaque
Sponsor: Istanbul Saglik Bilimleri University
Summary
Periodontitis is considered a focus of infection where oral bacteria, bacterial by-products or inflammatory mediators can interact with other parts of the organism via the blood. Periodontal pathogen components such as DNA, RNA or specific antigens of P. gingivalis, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Treponema denticola (T. denticola), Fusobacterium nucleatum (F. nucleatum) or Campylobacter rectus have been isolated from different tissues such as atheroma plaques, placenta, amniotic sac and respiratory tract. It has been reported that periodontitis may contribute to endothelial dysfunction leading to the formation of atherosclerosis.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2024-12-10
Completion Date
2026-03-30
Last Updated
2025-08-03
Healthy Volunteers
Not specified
Interventions
atheroma plaque
During the endarterectomy procedure, samples will be collected for study from some of the atheroma plaques routinely taken for pathology from patients.
dental plaque
Subgingival plaque samples will be collected from patients before the endarterectomy procedure.
Locations (1)
Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology
Istanbul, Turkey (Türkiye)