Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
Sponsor: Marwa Hisham Mohamed Salah Eldin
Summary
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation. The primary outcome is pain intensity measured at multiple intervals using a Visual Analogue Scale. The secondary outcome is the periapical expression of MMP-9 assessed via ELISA. The trial aims to determine whether treatment timing impacts inflammation and healing.
Official title: A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2025-08-01
Completion Date
2025-08-04
Last Updated
2025-08-03
Healthy Volunteers
No
Interventions
single visit instrumentation
root canal instrumentation will be done on single visit treatment
multiple visit instrumentation
root canal treatment will be done on two visits