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A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG
Sponsor: Ain Shams University
Summary
A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive and cardiac status post extubation
Key Details
Gender
All
Age Range
21 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-09-01
Completion Date
2026-08-31
Last Updated
2025-08-06
Healthy Volunteers
Yes
Interventions
Normal saline
After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU
Dexmedetomidine
After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU
Methylprednisolone
After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU
Locations (1)
Ain Shams University
Cairo, Cairo Governorate, Egypt