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RECRUITING
NCT07101588
PHASE4

Ruxolitinib-Decitabine Intensified Conditioning Regimen for AML: A Randomized Trial

Sponsor: Chinese PLA General Hospital

View on ClinicalTrials.gov

Summary

This study aims to determine whether the recurrence rate of high-risk acute myeloid leukemia CR1 patients who received allogeneic hematopoietic stem cell transplantation with the Ruxolitinib, Decitabine combined with Bu/Cy or BuF intensive pretreatment regimen is reduced compared with the traditional Bu/Cy or BuFpretreatment regimen.

Official title: Ruxolitinib and Decitabine-Enhanced Conditioning Versus Modified Bu/Cy or BuF Conditioning for the Impact on Relapse of Acute Myeloid Leukemia in First Complete Remission (CR1)After Allogeneic Hematopoietic Stem Cell Transplantation: A Multicenter, Prospective Randomized Controlled Trial

Key Details

Gender

All

Age Range

14 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

200

Start Date

2025-01-01

Completion Date

2028-12-30

Last Updated

2026-03-20

Healthy Volunteers

No

Interventions

COMBINATION_PRODUCT

Ruxolitinib, Decitabine

1. Decitabine: 20 mg/m²/day, administered from Day -15 to Day -10. 2. Ruxolitinib: * 10 mg twice daily (bid), Day -15 to Day -5 * 5 mg twice daily (bid), Day -4 to Day -3 * 5 mg once daily (Qd), Day -2

Locations (1)

Chinese PLA General Hospital

Beijing, Beijing Municipality, China