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RECRUITING
NCT07101601
PHASE1

Study of DM5167 in Patients With Advanced Solid Tumors

Sponsor: DIGMBIO

View on ClinicalTrials.gov

Summary

DM5167 is a second-generation of PARP inhibitor that selectively targets the PARP-1 enzyme. This results in less haematological toxicity and a high level of safety. The aim of the study is to assess the safety and tolerability of DM5167 in patients with advanced solid tumors not respond to other treatments.

Official title: An Open-label, Dose-finding, Phase 1 Study to Assess the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile, and to Explore the Pharmacodynamic Profile of DM5167 in Patients With Advanced Solid Tumors

Key Details

Gender

All

Age Range

19 Years - Any

Study Type

INTERVENTIONAL

Enrollment

58

Start Date

2024-10-24

Completion Date

2027-01-31

Last Updated

2025-08-03

Healthy Volunteers

No

Interventions

DRUG

DM5167

Once daily for 28 days

Locations (4)

Seoul National University Bundang Hospital

Gyeonggi-do, South Korea

Samsung Medical Center

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea