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Study of DM5167 in Patients With Advanced Solid Tumors
Sponsor: DIGMBIO
Summary
DM5167 is a second-generation of PARP inhibitor that selectively targets the PARP-1 enzyme. This results in less haematological toxicity and a high level of safety. The aim of the study is to assess the safety and tolerability of DM5167 in patients with advanced solid tumors not respond to other treatments.
Official title: An Open-label, Dose-finding, Phase 1 Study to Assess the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile, and to Explore the Pharmacodynamic Profile of DM5167 in Patients With Advanced Solid Tumors
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
58
Start Date
2024-10-24
Completion Date
2027-01-31
Last Updated
2025-08-03
Healthy Volunteers
No
Conditions
Interventions
DM5167
Once daily for 28 days
Locations (4)
Seoul National University Bundang Hospital
Gyeonggi-do, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea