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Occurrence of Acute Kidney Injury After CAR-T Cells Treatments in B-cell Lymphoma.
Sponsor: Hospices Civils de Lyon
Summary
The investigators want to describe the incidence of AKI after CAR-T cells therapy in B-cell lymphoma. With the aim of highlight risk factors in AKI occurrence. Then, look at outcomes in the subgroup with chronic kidney disease at baseline. Finally, the investigators will examine long term evolution of kidney function.
Official title: Incidence and Risk Factors of Acute Kidney Injury (AKI) After Anti-CD19 CAR-T Cells Treatments in B-cell Lymphoma and Long Term Evolution.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-04-01
Completion Date
2026-04-01
Last Updated
2025-08-03
Healthy Volunteers
No
Interventions
Incidence of acute kidney injury
* Creatinine measurement before lymphodepletion chemotherapy, before CAR-T cells injection (day 0) and at day 1, day 3, day 5, day 7, day 10, day 14, day 21 and day 28. * AKI according to 2012 KDIGO.
Describe risk factors in AKI occurrence.
Comparison of caracteristics between participants with AKI and participants without AKI : * Baseline caracteristics of participants : age, gender, BMI (Body mass index), medical history… * Caracteristics of hematology disease : severity of lymphoma, previous treatments (chemotherapy, autologous/allogenic stem cell transplant), type of CAR-T cells (axi-cel, tisa-cel) * Other adverse affects : cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) * Use of nephrotoxic medications Informations found in medical field.
Focus on patient with chronic kidney disease at baseline
Looking at the subgroup with chronic kidney disease at baseline : are the outcomes different in this population ? Efficacity of CAR-T ? More adverse effects ?
Long term evolution after treatment by CAR-T cells
Creatinine measurement 1 year after CAR-T treatment. Informations found in medical field.
Locations (1)
Nephrology department, Centre hospitalier Lyon Sud
Pierre-Bénite, France, France