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Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Sponsor: Thomas Jefferson University
Summary
Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.
Official title: PACESS: Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies
Key Details
Gender
FEMALE
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
825
Start Date
2025-08-26
Completion Date
2027-12
Last Updated
2025-09-03
Healthy Volunteers
No
Conditions
Interventions
Acetaminophen
Acetaminophen 1000 mg q6H
NSAID (Ketorolac/Ibuprofen)
NSAID (ketorolac 30 mg q6H for first 24 hours post-op followed by ibuprofen 600 mg q6H)
Locations (1)
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States