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Developing a New LIFU Neuromodulation Method to Suppress Tremor
Sponsor: University of Calgary
Summary
The investigators aim to apply low intensity focused ultrasound neuromodulation to patients with essential tremor to evaluate the efficacy of this intervention in reducing the amplitude of hand tremor compared to sham stimulation.
Official title: Developing a New Low-intensity Focused Ultrasound (LIFU) Neuromodulation Method to Suppress Tremor
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-09-15
Completion Date
2027-07-15
Last Updated
2025-08-05
Healthy Volunteers
No
Conditions
Interventions
Transcranial focused ultrasound stimulation
Parameters Range of values Fundamental frequency 250 kHz Transducer diameter 15 cm Focal distance 13.5 cm (steerable +/- 5-10 mm from the center) Pulse repetition frequency 100 Hz Duty cycle 10% Duration 2 min for each of the 7 foci Peak spatial intensity (Isppa) 10.0 W/cm2 Peak temporal average intensity (Ispta) 1.2 W/cm2 Mechanical index (MI) 0.48 \* Thermal index (TI) 0.8oC \*\*
Sham stimulation
Same set-up as for real stimulation but with without delivering any ultrasound stimulation