Clinical Research Directory

Inclusion Criteria: * Participants must have histologically confirmed NSCLC, Stages III or IV treated with palliative intent * Adults ≥ 18 years of age * ECOG performance status ≤ 3 * Clinical stability: defined as no clinical/radiographic progression within the last three months * Self-reported dyspnea, defined as score ≥ 2 on the modified Medical Research Council (mMRC) Dyspnea Scale * Participants must be fluent in written and spoken English Exclusion Criteria: * Participants being treated with curative intent for locally advanced NSCLC or oligometastatic NSCLC with concurrent chemotherapy and radiation will be excluded * Participants have evidence of clinical and/or radiographic progression * Mental impairment leading to inability to complete study requirements * High risk of fracture or spine instability (Mirels score ≥7 or SINS ≥7) * Any of the following cardiac exclusion criteria: * Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system * History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty or stenting within the past 6 months prior to the start of radiation therapy * Uncontrolled arrhythmias; individuals with rate-controlled atrial fibrillation for \> 1 month prior to start of radiation therapy may be eligible * Syncope * Acute myocarditis, pericarditis, or endocarditis * Acute pulmonary embolus or pulmonary infarction within the last 3 months * Acute thrombosis of lower extremities within the last 3 months * Suspected dissecting aneurysm * Pulmonary edema * Respiratory failure * Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise