Clinical Research Directory

Inclusion Criteria: * Volunteer for the trial, with the patient or their legal guardian signing the informed consent form. * Volunteers are not limited by gender, and the age range is from 18 to 75 years old, including both ends. * The patient is diagnosed with Alzheimer's disease (AD), supported by a positive amyloid PET scan. * The patient has completed Tau PET scan. Exclusion Criteria: * Individuals with a history of allergy to drugs chemically or biologically similar to TSPO, a history of atopy, or currently suffering from allergic diseases. * Use of anti-inflammatory drugs, including corticosteroids and immunosuppressants, within the past 14 days, which may interfere with the accuracy of inflammation imaging. * Presence of other coexisting neurological diseases, such as stroke, Parkinson's disease, brain tumors, or mental disorders, including depressive disorder and schizophrenia. * Severe cardiac, pulmonary, hepatic, or renal dysfunction, or uncontrolled systemic diseases; 5. Presence of metal implants contraindicated for MRI, including but not limited to cardiac pacemakers, artificial heart valves, and metal stents. * Claustrophobia or inability to tolerate prolonged examinations. * Pregnant women (defined as those with a positive urine pregnancy test) or breastfeeding women. * Patients whose physical condition is unsuitable for radioactive tracer-based imaging examinations. * Other circumstances deemed unsuitable for participation in the trial by the researcher.