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NOT YET RECRUITING
NCT07108959
NA

ESPB Versus Perioperative Iv Lidocaine Infusion on Proinflammatory Cytokines in Breast Cancer Surgeries

Sponsor: Alexandria University

View on ClinicalTrials.gov

Summary

The present study aims to compare the effect of ESPB versus perioperative iv lidocaine infusion on proinflammatory cytokines in breast cancer surgeries.

Official title: Effect of Ultrasound Guided Erector Spinae Plane Block Versus Perioperative Intravenous Lidocaine Infusion on Proinflammatory Cytokines in Breast Cancer Surgeries

Key Details

Gender

FEMALE

Age Range

30 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2025-08-01

Completion Date

2026-12-31

Last Updated

2025-08-07

Healthy Volunteers

No

Interventions

PROCEDURE

Erector spinae plane block (Group E)

The ultra sound probe will be placed on the paravertebral region in a Sagittal plane about 3 cm lateral to the T5 spinous process on the operating side to locate erector spinae muscle, rhomboid major and trapezius from inward (To reach T5, we used C7 as an anatomical landmark, which is the most prominent vertebrae in the back and count downwards to reach T5. To locate C7, we will use palpation or ultrasound guidance if there is difficulty in palpation). Following visualization of these muscles and the transverse process of T5, the skin will be infiltrated with 5 ml of 2% lidocaine, and then 30 ml bupivacaine 0.25% will be injected in the plane between the erector spinae muscle and transverse process using a 22-G 10-cm nerve block needle.

PROCEDURE

Lidocaine (drug)

Patients in group L will receive an initial bolus of lidocaine 1.5mg /kg over 10 minutes immediately before the induction of general anaesthesia then 1.5mg/kg/hr lidocaine infusion in a 50cc syringe pump intra operatively that will be stopped at the end of surgery.

Locations (1)

Faculty of Medicine , Alexandria University

Alexandria, Alexandria Governorate, Egypt