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Effect of Dexamethasone on Labour Induction in Term Pregnancies
Sponsor: Cairo University
Summary
The aim of the study is to assess the effect of dexamethasone on labour induction in term pregnancies. Primary outcome: The interval between initiation of induction and beginning of the active phase of labour. Secondary outcomes: * Duration of active phase of labour (starting with cervical dilatation of 4-5 cm up to full cervical dilatation). * Duration of second stage of labour * Mode of delivery. * Fetal outcome. Group A: Will receive one dose of IM dexamethasone sodium phosphate 8 mg (2 mL). Group B: Will receive vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h. Group C: Will receive one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2025-05-01
Completion Date
2025-09-15
Last Updated
2025-08-07
Healthy Volunteers
Yes
Conditions
Interventions
Dexamethasone (Decadron) 8mg IM injection
one dose of IM dexamethasone sodium phosphate 8 mg (2 mL) given at the start of labour induction
Misoprostol 25 mcg
vaginal misoprostol 25 μg tablets every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Both Misoprostol 25 mcg & Dexamethasone 8mg IM injection
one dose of IM dexamethasone sodium phosphate 8mg (2mL) with the first dose of vaginal misoprostol 25 μg tablets that will be given every 6 h, up to 4 tablets, for a maximum duration of 24 h.
Locations (1)
Cairo University Hospital (Kasr Al Ainy)
Cairo, Manial, Egypt