Clinical Research Directory

Inclusion Criteria: Community-acquired pneumonia group * Age ≥18 years old; * Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit; ④ Comply with the diagnostic criteria for community-acquired pneumonia in the Chinese Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia in Adults (2016 Edition); ⑤ The time from onset to enrollment was ≤8 days. Sepsis Group * Age ≥18 years old; * Sign the informed consent form; ③ According to the researcher's judgment, be able to comply with the research visit; * Patients who meets the sepsis 3.0 diagnostic criteria. Exclusion Criteria: Exclusion criteria * Respiratory failure related to underlying heart and lung diseases; * Severe liver and kidney dysfunction, pregnancy or lactation period; * Meet the indications for organ transplantation or have undergone organ transplantation surgery in the past; ④ Known HIV infection; ⑤ Screening: Those who have experienced unstable angina pectoris or myocardial infarction within 30 days prior to the screening and have not received vascular recanalization treatment, as well as those with extensive cerebral hemorrhage; ⑥ Situations where researchers determine that enrollment is not appropriate.