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Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease
Sponsor: The Cleveland Clinic
Summary
This study employs an exploratory, prospective, single center, naturalistic clinical trial design with a randomized crossover intervention.
Official title: Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease - The DREAMS-PD Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2025-11-22
Completion Date
2026-12-31
Last Updated
2025-12-15
Healthy Volunteers
No
Conditions
Interventions
Nighttime Deep Brain Stimulation with Varying Amplitude Settings
Participants will undergo three different nighttime-only Deep Brain Stimulation (DBS) settings in a randomized crossover design: 0% amplitude (stimulation off), 50% amplitude of their optimal clinical DBS settings, and full clinical DBS settings (100%). Each setting is applied for two weeks during sleep, over a total six-week home monitoring period. The intervention is designed to assess how varying levels of subthalamic nucleus DBS influence sleep quality and neural oscillatory activity. Only nighttime DBS settings are modified; daytime settings remain unchanged.
Locations (1)
Cleveland Clinic
Cleveland, Ohio, United States